IMMUNOLOGY2026™ Conference Recordings For Attendees-A unique subset of allergen specific T helper 2+17 tissue resident memory cells is established in a mouse model of allergic inflammation

A unique subset of allergen specific T helper 2+17 tissue resident memory cells is established in a mouse model of allergic inflammation

Back to course

Video Transcription

Video Summary

The speaker described a study of allergen-specific tissue-resident memory CD4 T cells in a mouse model of house dust mite–induced airway allergy. Using lineage tracing and single-cell RNA sequencing, the team found heterogeneous lung TRM2 populations, including a novel Th2+17 subset that co-expresses GATA3 and RORγT/IL-17. These cells persisted in the lung for up to one year, were antigen-specific, and could arise from Th2 cells after rechallenge. Similar Th2+17 cells were also detected in asthma patient lung data, suggesting they may contribute to severe, steroid-resistant asthma and represent a potential therapeutic target.

Meta Tag

Date April 18, 2026 10:29 AM - 10:44 AM

Room Ballroom

Session Major Symposium F: 20 Years of Th17 Cells: Discovery and Clinical Impact

Speaker Alice Taliento

Track Lymphocyte Differentiation and Peripheral Maintenance (LYM)

Year 2026

Keywords

tissue-resident memory CD4 T cells

house dust mite airway allergy

Th2+17 subset

single-cell RNA sequencing

steroid-resistant asthma

April 18, 2026 10:29 AM - 10:44 AM

Ballroom

Major Symposium F: 20 Years of Th17 Cells: Discovery and Clinical Impact

Alice Taliento

Lymphocyte Differentiation and Peripheral Maintenance (LYM)

2026